Sounds like you have experience using Affinity diagrams. I tend to use them often and think of each sticky note (my preferred method) as a piece of a puzzle. The ones that fit together form a cluster and there may be one or more clusters.
If the groupings make sense then you can use the grouping to better tell the story of your data. If building user profiles, you may end up with groups like goals, motivations, behaviors, etc… The clusters are themes that should not be named until they are settled, sort of like an open card sort.
I hope this helps. I tend to use Affinity diagrams for a lot to find themes. Right or wrong they are effective for me so I use them.